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c/retatrutide·posted 9 months ago by u/andres_sorensen

switched from 2.5mg to 2.4mg and the sulphur burps got better, not worse

Caution Well Actually ×9

Posting this because I searched for it and got nothing useful.

Setup: 12.5mg, week 61, constipation present but not ruining anything. I changed exactly one variable — TRIUMPH — and tracked it for 19 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

5,542 up / 4,906 down53% upvoted23 commentsid 1z139u3 Oct 2025

23 comments

15 in this archive, depth 3

best — the order this archive was captured in

u/kofi_balogun57 points·9 months ago·edited

Mechanistically the bit that matters is triple agonist. It explains most of the early profile and a decent chunk of the outcome.

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u/bilal_osei27 points·9 months ago

Mechanistically the bit that matters is triple agonist.

Disagree on that part. 98.3% and 98.4% on the same vial is normal.

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u/emil_wojcik82 points·9 months ago

Small correction: the trial was 20 weeks, not 3. Does not change your point but people will quote it.

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u/andres_sorensenOP36 points·9 months ago

Research use material only, no human-use approval anywhere. Posts must describe what happened, not instruct strangers.

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u/viktor_laurent44 points·9 months ago

the dosing is steep, the constipation reports are real, and nobody knows the human safety yet

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u/soren_nkemelu37 points·9 months ago

Crossposting this to c/sideeffects because the people who need it are not reading this community.

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[deleted]28 points·9 months ago

[deleted]

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u/hassan_nilsen15 points·9 months ago·edited

the weight curves are unusually steep, which makes predicting individual response harder

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u/careful_gradient_notes-30 points·9 months ago

Slight fix: the number was 98.6, not 98.7. Decimal point, but a fairly consequential one.

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u/nadia_trevino13 points·9 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/andres_sorensenOP6 points·9 months ago

Research use material only, no human-use approval anywhere. Posts must describe what happened, not instruct strangers.

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u/nikhil_lindqvist26 points·9 months ago

This is correct. Triple agonism is genuinely different.

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u/marta_vanhecke8 points·9 months ago·edited

phase 2 numbers are not maintenance numbers, cite the trial

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u/tired_ledger_notes7 points·9 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/incretin_ivyMOD26 points·9 months ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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