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c/retatrutide·posted 9 months ago by u/ewan_zielinski

22 months in and triple agonist is still the thing I get wrong

Caution Well Actually ×3

Trying to settle this properly because the thread from last year went in circles.

The claim: glucagon matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 23 months without either producing anything.

What would actually settle it is 31 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

993 up / 362 down73% upvoted18 commentsid 1yh42g21 Oct 2025

18 comments

12 in this archive, depth 4

best — the order this archive was captured in

u/elodie_grimaldi87 points·9 months ago

The glucagon component does different things than dual agonism. The sulphur burps are not just amplified versions.

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u/sena_teixeira42 points·9 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/honest_syringe3332 points·9 months ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/anya_moreau38 points·9 months ago

TRIUMPH phase 2 showed 99.1% weight loss but the injection-site soreness profile on the highest arm was rough. Phase 2 != phase 3.

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u/bilal_osei14 points·9 months ago

TRIUMPH phase 2 showed 99.1% weight loss but the injection-site soreness profile on the highest arm was rough.

Yes, exactly this, and it is the bit that took me 89 weeks to accept.

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u/reflux_report31 points·9 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/signe_villalobos9 points·9 months ago

Did you actually measure heart rate or is that a feeling?

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u/rosa_almeida2 points·9 months ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/crosspost_bot_no3 points·9 months ago

research use only, handling and analysis, not protocols

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u/marta_vanhecke2 points·9 months ago

research use only, handling and analysis, not protocols

Adding to this: dose escalation is doing more work than the comment implies.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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