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c/retatrutide·submitted 11 months ago by u/solene_ilunga

week 11 check-in — 31kg down, muscle cramps manageable, one thing confusing me

Cautionbranch of 10 comments

Genuinely asking, not being difficult. Everyone in c/newbiequestions repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I search I get 2 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is…

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10 comments, started 11 months ago
u/hassan_nilsen166 points·11 months ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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u/incretin_ivyMOD120 points·11 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/honest_syringe_202582 points·11 months ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/solene_ilunga50 points·11 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/solene_ilungaOP35 points·11 months ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/ewan_marchand8 points·11 months ago

nobody should be giving this to anyone without extensive monitoring

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u/careful_gradient3251 points·11 months ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/farid_molnar28 points·11 months ago

triple agonism is glucagon, do not generalise

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u/zeynep_mbeki23 points·11 months ago

triple agonism is glucagon, do not generalise

Yes, exactly this, and it is the bit that took me 24 weeks to accept.

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u/lina_bruun-33 points·11 months ago

Not convinced. The evidence does not support that reading.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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