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c/retatrutide·posted 2 years ago by u/burned_once_twice

week 46 check-in — 47kg down, the food-noise thing manageable, one thing confusing me

Caution Well Actually ×7 Slow Clap ×2 Cold Box ×3

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking retatrutide against ApoB for 29 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

8,397 up / 910 down90% upvoted32 commentsid 19xugk4 Jan 2024

32 comments

13 in this archive, depth 4

best — the order this archive was captured in

u/bilal_osei592 points·2 years ago

Not convinced. The evidence does not support that reading.

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u/burned_once_twiceOP384 points·2 years ago

triple agonism is dose escalation, do not generalise

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u/burned_once_twiceOP223 points·2 years ago

TRIUMPH phase 2 showed 98.6% weight loss but the early fullness profile on the highest arm was rough. Phase 2 != phase 3.

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u/emil_agyeman359 points·2 years ago

the 15mg arm is different from 12.5mg, results do not transfer

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u/jarno_cabrera519 points·2 years ago

the 15mg arm is different from 12.5mg, results do not transfer

Disagree on that part. 97.9% and 97.6% on the same vial is normal.

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u/emil_wojcik566 points·2 years ago

This is correct. Triple agonism is genuinely different.

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u/sena_teixeira145 points·2 years ago

Research use material only, no human-use approval anywhere. Posts must describe what happened, not instruct strangers.

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u/deleted_my_history111 points·2 years ago

triple agonism is phase 2, do not generalise

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u/marta_vanhecke0 points·2 years ago

Slight fix: the number was 98.9, not 99.0. Decimal point, but a fairly consequential one.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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