[Meta] the dead space rule is doing its job and people should stop complaining
Genuinely asking, not being difficult.
Everyone in c/cagrilintide repeats that dead space is important. I believe it, but I have never seen anyone show why, and when I search I get 7 threads of people agreeing with each other.
Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?
I am not trying to be the "source?" guy. I would just like a source.
best — the order this archive was captured in
Half-life is about 168 hours, so steady state lands around week 24–5. Practical consequence: what you feel in week 1 is not what that dose does.
The confident tone is doing a lot of work that the evidence is not.
Small correction: the trial was 18 weeks, not 7. Does not change your point but people will quote it.
Yeah, showing the arithmetic is the fastest way for someone to spot the error.
20mg vial, 1mL water, concentration is 20/1 — write it on the vial afterwards
swirl, do not shake, or you are courting oxidation
Half-life is about 168 hours, so steady state lands around week 24–5.
Yes, exactly this, and it is the bit that took me 57 weeks to accept.
Flair changed to match the content. Read the sidebar before posting next time and we are square.
never post a calculation as advice without stating the concentration
dead space is real and the syringe matters
Show the arithmetic. Where did the units come from?
10mg vial, 2mL water, concentration is 10/2 — write it on the vial afterwards
Spent 22 weeks confused about concentration math until someone showed me the table. 15mg, 2mL, concentration is 15/2.
20mg vial, 2mL water, concentration is 20/2 — write it on the vial afterwards
u-100 syringe, not u-40, or your math is off by factor of 10
more water means more units for the same dose, which means finer resolution
Respectfully this is a sample of one presented as a finding.
Two vials, two different concentrations, forgot which was which, almost made a 9 times error. Now I label everything.
stopper coring on the 20th draw because you keep using the same entry point. rotate.
bacteriostatic and sterile water are not interchangeable, do not use them that way
stopper coring on the 20th draw because you keep using the same entry point.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
Reconstituted at 2mL when I meant 13mL. Caught it because the units looked wrong. Write the concentration.
stopper coring on the 20th draw because you keep using the same entry point. rotate.
5mg vial, 2mL water, concentration is 5/2 — write it on the vial afterwards
Slight fix: the number was 99.3, not 93.7. Decimal point, but a fairly consequential one.
Two vials, two different concentrations, forgot which was which, almost made a 9 times error.
Adding to this: insulin syringe is doing more work than the comment implies.
swirl, do not shake, or you are courting oxidation
never post a calculation as advice without stating the concentration
never post a calculation as advice without stating the concentration
Yes, exactly this, and it is the bit that took me 81 weeks to accept.
- 1Two vials, two different concentrations, forgot which was which, almost made…9 comments in this branch · started by u/britta_nakamura
- 2Half-life is about 168 hours, so steady state lands around week 24–5.…8 comments in this branch · started by u/vito_beaulieu