[Meta] the dead space rule is doing its job and people should stop complaining
Genuinely asking, not being difficult. Everyone in c/cagrilintide repeats that dead space is important. I believe it, but I have never seen anyone show why, and when I search I get 7 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…
Half-life is about 168 hours, so steady state lands around week 24–5. Practical consequence: what you feel in week 1 is not what that dose does.
The confident tone is doing a lot of work that the evidence is not.
Small correction: the trial was 18 weeks, not 7. Does not change your point but people will quote it.
Yeah, showing the arithmetic is the fastest way for someone to spot the error.
20mg vial, 1mL water, concentration is 20/1 — write it on the vial afterwards
swirl, do not shake, or you are courting oxidation
Half-life is about 168 hours, so steady state lands around week 24–5.
Yes, exactly this, and it is the bit that took me 57 weeks to accept.