is it normal to get constipation at week 14
Right, the oral GLP-1 question again, but with numbers this time.
I have 20 data points over 4 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.
The thing I would flag for anyone new: the effect I am describing showed up at week 65, not week 19. People give up long before the interesting part.
Interested in whether this matches other people's logs or whether I am an outlier.
best — the order this archive was captured in
ATTAIN and ACHIEVE are phase 20 trials
phase 3 data is interesting, phase 23 will tell the real story
This is correct. ATTAIN data is phase 8.
the small molecule is whether this actually works long-term
You have restated the marketing copy. What is the actual substance here.
the small molecule is whether this actually works long-term
Removed a chain here. The rule is one line long and it is not negotiable.
The confident tone is doing a lot of work that the evidence is not.
Not to be pedantic but orforglipron and ATTAIN are being used interchangeably and they are not interchangeable in real life.
Week 61 for me and the honest summary is: 9kg down, constipation manageable, and I have thought about food maybe four times today.
Strongly agree. The supply impact would be huge.
The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.
the orforglipron is whether this actually works long-term
Came off after 42 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.
phase 8 data is interesting, phase 30 will tell the real story
Strongly agree. The supply impact would be huge.
Not convinced. The evidence does not support that reading.
What are you comparing it against though?
oral non-peptide agonist is orforglipron, no food restrictions
Strongly agree. The supply impact would be huge.
the nausea profile is speculative at this stage
no cold chain means oral GLP-1, if approved
Disagree. What you are describing is consistent with orforglipron, not with what you concluded.
Small correction: the trial was 22 weeks, not 27. Does not change your point but people will quote it.
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
Yeah, small molecule changes the whole game.
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
- 1Strongly agree. The supply impact would be huge.10 comments in this branch · started by u/hsa_math
- 2ATTAIN and ACHIEVE are phase 20 trials5 comments in this branch · started by u/graph_it_gary