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c/orforglipron·posted 1 year ago by u/search_before_post

stalled for 11 weeks at 2.5mg and I refuse to panic this time

Paper

Genuinely asking, not being difficult.

Everyone in c/sideeffects repeats that non-peptide is important. I believe it, but I have never seen anyone show why, and when I search I get 23 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

2,054 up / 2,136 down50% upvoted15 commentsid x4h3m12 Jan 2025

15 comments

15 in this archive, depth 5

best — the order this archive was captured in

u/trialwatch_theotrial nerd8 points·1 year ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/paloma_stanescu6 points·1 year ago

small molecule, not a peptide, purity discussion is different

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[removed]2 points·1 year ago

[removed by moderator]

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u/greta_nilsen4 points·1 year ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/trialwatch_theoMOD3 points·1 year ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/piotr_bruun4 points·1 year ago

Yeah, small molecule changes the whole game.

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u/viktor_laurent2 points·1 year ago

cite ATTAIN/ACHIEVE arms specifically

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u/discount_math_dm1 point·1 year ago

the non-peptide is whether this actually works long-term

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u/joaquin_trevino1 point·1 year ago

small molecule purity is different testing than peptides

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u/erez_yilmaz1 point·1 year ago

Inter-lab variance on this kind of assay is routinely 1–2 points.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/pancreatitis_scare3 points·1 year ago

cite ATTAIN/ACHIEVE arms specifically

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u/kenji_laurent-31 points·1 year ago

Yeah, small molecule changes the whole game.

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u/reship_roulette2 points·1 year ago

ATTAIN and ACHIEVE are phase 9 trials

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u/erez_yilmaz3 points·1 year ago

availability speculation must be flaired Speculation

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u/lucia_bruun3 points·1 year ago

Yeah, small molecule changes the whole game.

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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