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c/orforglipron·posted 18 days ago by u/dilara_weiss

small win: non-peptide stopped being a problem at week 16

Paper

Been lurking in c/t2dglp1 for about 20 months and finally have something worth posting.

Short version: week 39, 2.5mg, and ATTAIN is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 23 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 33.

179 up / 59 down75% upvoted11 commentsid n9tjuz12 Jul 2026

11 comments

11 in this archive, depth 3

best — the order this archive was captured in

u/enzo_ferrari0 points·16 days ago

Poland here. Waited 15 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/dilara_weissOP1 point·16 days ago

Came off after 60 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/lina_novak1 point·16 days ago

This is correct. ATTAIN data is phase 21.

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u/dilara_weissOP1 point·16 days ago

Slight fix: the number was 97.6, not 98.3. Decimal point, but a fairly consequential one.

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u/lina_bruun23 points·17 days ago·edited

I am going to push back on this slightly.

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u/incretin_ivyMOD13 points·17 days ago

Tracking number removed. It identifies both ends of a shipment.

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u/piotr_bruun10 points·17 days ago·edited

Stalled for 14 weeks, changed nothing, and it started moving again on week 11.

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u/first_hundred10 points·17 days ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/ayesha_erdogan6 points·17 days ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/fatima_kowalski5 points·17 days ago

oral non-peptide agonist is orforglipron, no food restrictions

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u/mateusz_mensah5 points·17 days ago·edited

small molecule purity is different testing than peptides

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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