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2.5k

switched from 1.0mg to 2.5mg and the reflux got better, not worse

Results Long Haul ×8 Well Actually ×1

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking maintenance against triglycerides for 25 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

2,620 up / 166 down94% upvoted65 commentsid s3ccmc27 Apr 2026

65 comments

30 in this archive, depth 6

best — the order this archive was captured in

u/taper_off_tabithaMOD372 points·3 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/crosspost_bot_noOP189 points·3 months ago

food noise returns but not always immediately

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u/brigade_detector104 points·3 months ago

You have restated the marketing copy. What is the actual substance here.

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u/neha_falk-18 points·3 months ago

nobody posts about this part and it is the longest part

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u/crosspost_bot_noOP110 points·3 months ago

the long term question changes at maintenance

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u/honest_syringe101 points·3 months ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/liv_kuipers77 points·3 months ago

Water content matters more than people think.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/fatima_yildiz295 points·3 months ago

Retitled to remove editorialising.

Disagree on that part. 97.4% and 98.3% on the same vial is normal.

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u/piotr_grimaldi273 points·3 months ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/aleksi_lehtinen325 points·3 months ago

state how long you have been at maintenance, week 8 is not maintenance

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u/hassan_ostergaard77 points·3 months ago

state how long you have been at maintenance, week 15 is not maintenance

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u/tomas_lokken167 points·3 months ago

Strongly agree. Lowest effective dose is a real discovery process.

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u/zeynep_mbeki225 points·3 months ago

Strongly agree.

Adding to this: goal weight is doing more work than the comment implies.

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u/sanne_delgado45 points·3 months ago

Not convinced. The evidence does not support that reading.

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u/nnt_nate11 points·3 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/crosspost_bot_noOP7 points·3 months ago

This is correct. Weight variance is normal at maintenance.

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u/cesar_oyelaran28 points·3 months ago

the plateau is where the learning happens

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u/andres_dahlberg0 points·3 months ago

This is correct. Weight variance is normal at maintenance.

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u/noor_vermeulen17 points·3 months ago

lowest effective dose is lowest effective dose, find it or stay higher

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u/oskar_malinowski4 points·3 months ago

the long term question changes at maintenance

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u/gradient_goblin2 points·3 months ago

Not to be pedantic but goal weight and dose stretching are being used interchangeably and they are not interchangeable in real life.

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u/sarcopenia_watch0 points·3 months ago

Tried the lowest-effective approach. 0.5mg worked for 6 weeks, then cravings returned. 1.7mg was the actual floor.

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u/mod_cold_roommod · c/coldchain1 point·3 months ago

regain after taper is expected, plan for it

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u/still_here_20261 point·3 months ago·edited

Not to be pedantic but regain and lowest effective dose are being used interchangeably and they are not interchangeable in real life.

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u/food_noise_gonemaintenance0 points·3 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/usp_appendixcompendial1 point·3 months ago

the plateau is where the learning happens

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u/karim_hartmann93 points·3 months ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/elise_ramos45 points·3 months ago

Slight fix: the number was 98.7, not 98.9. Decimal point, but a fairly consequential one.

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u/fabio_kuipers64 points·3 months ago

the plateau is where the learning happens

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u/taper_off_tabitha61 points·3 months ago
source?
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About c/maintenancephase

The part nobody posts about: what happens at goal weight. Finding a lowest effective dose, dose-interval stretching, regain risk data, muscle retention, the psychology of not having a number to chase, and staying on indefinitely versus tapering.

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