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c/glp1women·posted 10 months ago by u/mei_cardoso

14 months in and insulin resistance is still the thing I get wrong

PCOS Receipts ×8

Posting this because I searched for it and got nothing useful.

Setup: 7.5mg, week 57, sulphur burps present but not ruining anything. I changed exactly one variable — insulin resistance — and tracked it for 15 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

1,135 up / 245 down82% upvoted54 commentsid 6w7ama23 Sep 2025

54 comments

27 in this archive, depth 5

best — the order this archive was captured in

u/low_appetite_lisaMOD89 points·10 months ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/ferran_laurent61 points·10 months ago

This is correct. PCOS is real.

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u/kian_solberg-37 points·10 months ago

This is correct.

Disagree on that part. 96.2% and 96.8% on the same vial is normal.

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u/kenji_demir55 points·10 months ago

Yeah, contraception is under-researched.

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u/mei_cardosoOP36 points·10 months ago

the cycle tracking data matters, keep it private

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u/mei_cardosoOP36 points·10 months ago

Came off after 93 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/column_dead_volume43 points·10 months ago

Came off after 93 weeks for financial reasons.

Yes, exactly this, and it is the bit that took me 50 weeks to accept.

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u/neha_falk12 points·10 months ago

contraception interaction claims need citation

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u/rasmus_petrescu35 points·10 months ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/mateusz_mensah38 points·10 months ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/step_therapy_s21 points·10 months ago
okay but what dose
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u/tl_dr_tina5 points·10 months ago

hair-loss on contraception is real

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u/katrin_diallo6 points·10 months ago

contraception interaction claims need citation

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u/samir_falk15 points·10 months ago

The nausea was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/idris_kimani12 points·10 months ago

Strongly agree. Cycle changes are documented.

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u/honest_syringe_20255 points·10 months ago·edited

perimenopause and menopause weight physiology

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u/katrin_diallo4 points·10 months ago·edited

pregnancy and trying-to-conceive get clinician pointer, not community advice

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u/vitamin_d_void3 points·10 months ago

Has anyone actually got this in writing, or is it forum lore at this point?

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u/careful_gradient1 point·10 months ago

cycle changes are real and under-researched

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u/enzo_fonseca8 points·10 months ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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[deleted]3 points·10 months ago

[deleted]

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u/mei_cardosoOP1 point·10 months ago

PCOS and insulin resistance

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u/pavel_kravchenko11 points·10 months ago

contraception interaction claims need citation

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u/karl_fischer_kev6 points·10 months ago

Sweden here. Waited 6 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/viktor_erdogan1 point·10 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/zeynep_weiss2 points·10 months ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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About c/glp1women

The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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  1. Pregnancy and trying-to-conceive questions get a clinician pointer, not community advice.
  2. Contraception interaction claims need a citation.
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