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Single comment threadYou are looking at one branch of tried incretin for 21 weeks. here is what happened. — 13 comments in the full submission. View in context.
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c/glp1science·submitted 4 months ago by u/split_dose_sceptic

tried incretin for 21 weeks. here is what happened.

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Long-ish post, sorry. tl;dr at the bottom. I have been tracking receptor against triglycerides for 19 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab,…

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6 comments, started 4 months ago
u/enzo_petrescu31 points·4 months ago

Strongly agree. Central appetite is real but people overstate it.

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u/formulary_fighterappeals24 points·4 months ago

Yeah, the incretin mechanism is doing the work here.

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u/greta_lokken11 points·4 months ago

Which paper are you quoting?

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u/priya_guerrero10 points·4 months ago

do not extrapolate rodent data to human dosing without saying so

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u/yusuf_ramos10 points·4 months ago

receptor distribution matters, GLP-1 is not everywhere

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u/noor_hovland7 points·4 months ago

This is correct. Rodent data is investigational, not predictive.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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