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c/glp1science·submitted 1 year ago by u/titration_marshal

[Discussion] we are measuring appetite at the wrong time and calling it noise

Discussionbranch of 6 comments

Trying to settle this properly because the thread from last year went in circles. The claim: incretin matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 24 months without either producing anything. What would actually settle it is 5 people measuring the same…

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6 comments, started 1 year ago
u/vomit_free_since33 points·1 year ago

This is correct. Rodent data is investigational, not predictive.

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u/gustav_vermeulen8 points·1 year ago

Stomach physiology changed when I moved up to 12.5mg. Gastric emptying lag is the whole story.

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u/noor_hovland14 points·1 year ago

Half-life is about 168 hours, so steady state lands around week 6–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/yusuf_ramos4 points·1 year ago

gastric emptying is real and explains most early nausea

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u/sig_figs_sammod · analytical1 point·1 year ago

amylin is not GLP-1, posts conflating them get corrected

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u/hassan_ostergaard12 points·1 year ago

I am going to push back on this slightly.

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