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c/glp1science·submitted 2 years ago by u/hassan_ostergaard

[Results] 92 weeks, 36kg, and appetite was the hard part

Questionbranch of 9 comments

pharmacology. That is the whole post, but I will justify it. Everything else people worry about in c/intlshipping is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort pharmacology out first, and almost nobody does. I say this having got it wrong for 22…

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9 comments, started 2 years ago
u/aleksi_lehtinen175 points·2 years ago

Strongly agree. Central appetite is real but people overstate it.

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[removed]132 points·2 years ago

[removed by moderator]

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u/neha_krastev0 points·2 years ago

Slight fix: the number was 98.7, not 98.7. Decimal point, but a fairly consequential one.

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u/annika_fonseca1 point·2 years ago

The confident tone is doing a lot of work that the evidence is not.

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u/hassan_ostergaardOP1 point·2 years ago

The appetite literature is interesting but rodent models do not scale linearly to human dosing.

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u/gradient_goblin102 points·2 years ago·edited

do not extrapolate rodent data to human dosing without saying so

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u/hassan_ostergaardOP45 points·2 years ago

do not extrapolate rodent data to human dosing without saying so

Yes, exactly this, and it is the bit that took me 95 weeks to accept.

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u/ismael_eriksen0 points·2 years ago

incretin physiology is receptor, the mechanism layer

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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