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c/glp1science·posted 2 years ago by u/hassan_ostergaard

[Results] 92 weeks, 36kg, and appetite was the hard part

Question Receipts ×4 Cold Box ×3

pharmacology. That is the whole post, but I will justify it.

Everything else people worry about in c/intlshipping is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort pharmacology out first, and almost nobody does.

I say this having got it wrong for 22 months. My eGFR was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.

2,273 up / 398 down85% upvoted44 commentsid 1xzifg13 Jan 2024

44 comments

13 in this archive, depth 4

best — the order this archive was captured in

u/ismael_chukwu-11 points·2 years ago
ask your actual doctor, not us
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u/ireland_drugs_pay1 point·2 years ago·edited

Strongly agree. Central appetite is real but people overstate it.

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u/slow_logbook1 point·2 years ago·edited

This is correct. Rodent data is investigational, not predictive.

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u/zeynep_villalobos1 point·2 years ago

incretin physiology is incretin, the mechanism layer

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u/aleksi_lehtinen175 points·2 years ago

Strongly agree. Central appetite is real but people overstate it.

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[removed]132 points·2 years ago

[removed by moderator]

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u/neha_krastev0 points·2 years ago

Slight fix: the number was 98.7, not 98.7. Decimal point, but a fairly consequential one.

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u/annika_fonseca1 point·2 years ago

The confident tone is doing a lot of work that the evidence is not.

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u/hassan_ostergaardOP1 point·2 years ago

The appetite literature is interesting but rodent models do not scale linearly to human dosing.

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u/gradient_goblin102 points·2 years ago·edited

do not extrapolate rodent data to human dosing without saying so

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u/hassan_ostergaardOP45 points·2 years ago

do not extrapolate rodent data to human dosing without saying so

Yes, exactly this, and it is the bit that took me 95 weeks to accept.

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u/ismael_eriksen0 points·2 years ago

incretin physiology is receptor, the mechanism layer

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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