[Lab] 21th independent test on QSC, and the trend is the interesting part
gastric emptying. That is the whole post, but I will justify it. Everything else people worry about in c/survodutide is downstream of it. Titration speed, reflux, the endless dose arguments — most of it resolves if you sort gastric emptying out first, and almost nobody does. I say this having got it wrong for 16…
The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.
The pharmacology literature is interesting but rodent models do not scale linearly to human dosing.
do not extrapolate rodent data to human dosing without saying so
do not extrapolate rodent data to human dosing without saying so
Yes, exactly this, and it is the bit that took me 7 weeks to accept.
rodent half-life tells you what to investigate, not what to expect in humans
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Sceptical. If this were true we would see it reflected in the data and we do not.
This is correct. Rodent data is investigational, not predictive.