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c/glp1science·posted 1 year ago by u/second_week_sceptic

what changed for me between week 35 and week 84

Paper Receipts ×2 Cold Box ×3 Well Actually ×3

Trying to settle this properly because the thread from last year went in circles.

The claim: mechanism matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 11 months without either producing anything.

What would actually settle it is 27 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

3,551 up / 332 down91% upvoted27 commentsid 1rmful11 May 2025

27 comments

14 in this archive, depth 5

best — the order this archive was captured in

u/ireland_drugs_pay367 points·1 year ago

Mechanistically the bit that matters is half-life. It explains most of the early profile and a decent chunk of the outcome.

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u/second_week_scepticOP270 points·1 year ago

central appetite signalling is real but people overweight it

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u/whois_wanda203 points·1 year ago

central appetite signalling is real but people overweight it

Disagree on that part. 97.4% and 98.3% on the same vial is normal.

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u/yannick_barros0 points·1 year ago

Yeah, the incretin mechanism is doing the work here.

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u/kian_balogun0 points·1 year ago

Stomach physiology changed when I moved up to 7.5mg. Gastric emptying lag is the whole story.

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u/nhs_waitlist_nUK1 point·1 year ago

do not extrapolate rodent data to human dosing without saying so

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u/nadia_fonseca1 point·1 year ago

Which paper are you quoting?

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u/sig_figs_samMOD140 points·1 year ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/laila_almeida164 points·1 year ago

Which paper are you quoting?

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u/brigade_detector111 points·1 year ago·edited

glucagon-receptor contribution is incretin for dual and triple agonism

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[deleted]42 points·1 year ago

[deleted]

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u/gradient_goblin25 points·1 year ago·edited

cite the paper: journal, year, first author, links optional

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u/flair_enthusiast88 points·1 year ago
good post. terrible flair.
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u/ingrid_correia37 points·1 year ago

gastric emptying is real and explains most early nausea

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About c/glp1science

The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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