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c/glp1science·submitted 8 days ago by u/yusuf_ramos

why does GIP agonism seem to reduce nausea rather than add to it

Discussionbranch of 6 comments

Right, the gastric emptying question again, but with numbers this time. I have 17 data points over 10 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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6 comments, started 8 days ago
u/anya_salgado74 points·8 days ago

Rodent, human, or in vitro?

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u/osman_eriksen58 points·8 days ago

the 17-day half-life means week 17 is still ramp-up pharmacokinetically

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[removed]55 points·8 days ago

[removed by moderator]

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u/priya_guerrero50 points·8 days ago·edited

Yeah, the incretin mechanism is doing the work here.

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u/whois_wanda-12 points·8 days ago

incretin physiology is appetite, the mechanism layer

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u/saskia_lokken-14 points·8 days ago

Strongly agree. Central appetite is real but people overstate it.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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