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c/compounding·posted 1 year ago by u/hugo_bergstrom

API source: the version I wish someone had shown me in week 1

Discussion Long Haul ×6 Cold Box ×1 Clean Column ×1

Confession thread, sort of.

I went from 0.5mg to 12.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 18 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have injection-site soreness I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 87 reads it before doing the same thing.

3,769 up / 207 down95% upvoted44 commentsid katnh19 Jul 2025

44 comments

24 in this archive, depth 5

best — the order this archive was captured in

u/niels_roos227 points·1 year ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/vikram_mbeki150 points·1 year ago

What is the actual shortage list status right now?

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u/solene_eriksen120 points·1 year ago

no pharmacy referral codes, naming is fine, recruiting is not

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u/escrow_evangelist103 points·1 year ago

Which state? Rules vary.

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u/rekha_mwangi84 points·1 year ago

Yeah, 503A and 503B are different regulatory animals.

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[removed]73 points·1 year ago

[removed by moderator]

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u/sofia_danquah24 points·1 year ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/pavel_kravchenko44 points·1 year ago

the 503A/503B distinction is load-bearing, do not blur it

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u/teodor_duarte29 points·1 year ago·edited

the 503A/503B distinction is load-bearing, do not blur it

Adding to this: API source is doing more work than the comment implies.

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u/hugo_bergstromOP13 points·1 year ago

the shortage list is temporary, it ends and compounding becomes illegal again

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u/hugo_bergstromOP66 points·1 year ago·edited

Moved states and the compounding landscape changed completely. Different rules, different pharmacies, different costs.

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u/niels_roos42 points·1 year ago

API transparency is the question that separates good compounders from sketchy ones

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u/rina_sobczak9 points·1 year ago

Are we talking 503A or 503B?

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u/step_count_stan18 points·1 year ago

Did they tell you their API source or dodge the question?

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u/emil_okwuosa-6 points·1 year ago

Disagree. What you are describing is consistent with 503B, not with what you concluded.

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u/tobias_vukovic40 points·1 year ago

The 503A pharmacy I used lost their shortage list eligibility. Same day, compounding became illegal. Rules are real.

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u/ismael_pires20 points·1 year ago

telehealth prescriber models exist, pricing differs by state

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u/hugo_bergstromOP9 points·1 year ago

Small correction: the trial was 19 weeks, not 24. Does not change your point but people will quote it.

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u/sofia_nascimento23 points·1 year ago

Yeah, 503A and 503B are different regulatory animals.

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u/rania_diallo33 points·1 year ago

Moved states and the compounding landscape changed completely. Different rules, different pharmacies, different costs.

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u/blunt_coldbox_notes25 points·1 year ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/jonas_eriksen14 points·1 year ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/lukas_delgado20 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/medutest_mel9 points·1 year ago

Yeah, 503A and 503B are different regulatory animals.

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About c/compounding

Compounded GLP-1s as a supply route: the 503A/503B distinction, the shortage-list mechanics that made compounding legal and then didn't, state board rules, telehealth prescriber models, and what a compounding pharmacy will and will not tell you about its API source.

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c/compounding rules
  1. Regulatory claims need a citation to the actual rule, notice or docket.
  2. No pharmacy referral codes. Naming a pharmacy is fine; recruiting for it is not.
  3. API source questions are on-topic and pharmacies dodging them is newsworthy.
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  5. Not medical advice. Describe what you did; never prescribe to a stranger.
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