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c/coldchain·posted 1 months ago by u/coldchain_karen

the Netherlands: stability, and what it actually costs here

Discussion Clean Column ×3 Slow Clap ×2

Confession thread, sort of.

I went from 15mg to 7.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 18 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have reflux I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 90 reads it before doing the same thing.

3,761 up / 2,750 down58% upvoted53 commentsid qdp9zt21 Jun 2026

53 comments

17 in this archive, depth 4

best — the order this archive was captured in

u/sten_palacios207 points·1 months ago

Disagree. What you are describing is consistent with excursion, not with what you concluded.

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u/milos_vestergaard298 points·1 months ago

Yeah, data logger is the only acceptable proof.

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u/sten_palacios142 points·1 months ago

lyophilised powder is far more forgiving than reconstituted solution

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u/isabela_nilsen56 points·1 months ago

Peak temperature and how long at that temperature?

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u/iman_castellanos39 points·1 months ago

stability after excursion is not zero, it is dose-dependent

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[removed]14 points·1 months ago

[removed by moderator]

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u/tidy_vialdrawer_watch28105 points·1 months ago

I am going to push back on this slightly.

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u/fatima_yildiz36 points·1 months ago

gel packs last 24 hours, after that you are relying on the box itself

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u/coldchain_karenOPcold chain15 points·1 months ago

Customs clearance took 19 days. Package sat unrefrigerated during that. Powder tested clean after, reconstituted solution probably would not have.

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u/ines_lindqvist70 points·1 months ago·edited

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/split_dose_sceptic95 points·1 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/marit_laurent138 points·1 months ago

a warm courier van is a bigger problem for a mixed vial than for dry powder

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u/britt_okwuosa63 points·1 months ago

Strongly agree. Peak temperature is not the whole story.

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u/coldchain_karenOPcold chain37 points·1 months ago

Reconstituted or dry powder?

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u/split_dose_sceptic42 points·1 months ago

Denmark to Denmark takes 21 days on average, variance is 22 days

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u/cesar_teixeira15 points·1 months ago

lyophilised powder is far more forgiving than reconstituted solution

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u/emeka_delgado50 points·1 months ago

Peak temperature and how long at that temperature?

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About c/coldchain

Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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