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c/coldchain·submitted 1 months ago by u/coldchain_karen

the Netherlands: stability, and what it actually costs here

Discussionbranch of 6 comments

Confession thread, sort of. I went from 15mg to 7.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 18 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have reflux I did…

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6 comments, started 1 months ago
u/sten_palacios207 points·1 months ago

Disagree. What you are describing is consistent with excursion, not with what you concluded.

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u/milos_vestergaard298 points·1 months ago

Yeah, data logger is the only acceptable proof.

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u/sten_palacios142 points·1 months ago

lyophilised powder is far more forgiving than reconstituted solution

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u/isabela_nilsen56 points·1 months ago

Peak temperature and how long at that temperature?

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u/iman_castellanos39 points·1 months ago

stability after excursion is not zero, it is dose-dependent

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[removed]14 points·1 months ago

[removed by moderator]

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Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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