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c/coa·posted 2 years ago by u/bastian_aalto

[Discussion] can we stop arguing about area percent until somebody posts a number

Discussion Receipts ×1 Long Haul ×2 Well Actually ×3

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking related substances against eGFR for 29 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

3,668 up / 642 down85% upvoted56 commentsid 1x7qnl29 Feb 2024

56 comments

21 in this archive, depth 5

best — the order this archive was captured in

u/dead_space_doug291 points·2 years ago·edited

Titration speed is a side-effect dial far more than an efficacy dial.

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u/bastian_aaltoOP209 points·2 years ago

redact your own name, not the vendor's batch details

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u/cormac_pereira176 points·2 years ago
okay but what dose
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u/bastian_aaltoOP255 points·2 years ago

chromatogram or it did not happen

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u/kavya_verhoeven212 points·2 years ago

I am going to push back on this slightly.

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u/ghrp_history135 points·2 years ago

PDF metadata is checkable in fifteen seconds

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u/laila_yilmaz45 points·2 years ago

PDF metadata is checkable in fifteen seconds

Adding to this: related substances is doing more work than the comment implies.

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u/bastian_aaltoOP23 points·2 years ago

The confident tone is doing a lot of work that the evidence is not.

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u/sofia_ferreira6 points·2 years ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/nikhil_lindqvist81 points·2 years ago

the counterion is part of the mass you paid for

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u/coa_collectorMOD65 points·2 years ago

Tracking number removed. It identifies both ends of a shipment.

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u/emil_agyeman49 points·2 years ago

area% is not mass%, and here is exactly why it matters

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u/rohan_steiner39 points·2 years ago

PDF metadata is checkable in fifteen seconds

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u/laila_yilmaz46 points·2 years ago

Strongly agree. Mass% and area% are answering different questions on the same document.

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u/ghrp_history0 points·2 years ago

Batch number and date of analysis? Both are load-bearing.

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u/purity_pedantanalytical0 points·2 years ago

chromatogram or it did not happen

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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