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c/coa·posted 1 year ago by u/anecdata_annie

is it normal to get early fullness at week 14

Lab Clean Column ×7 Receipts ×3 Slow Clap ×2

Confession thread, sort of.

I went from 2.5mg to 1.0mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 4 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have sulphur burps I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 34 reads it before doing the same thing.

9,174 up / 1,049 down90% upvoted33 commentsid 1v2buz28 Jun 2025

33 comments

19 in this archive, depth 4

best — the order this archive was captured in

u/emeka_beaulieu1.1k points·1 year ago

This is the correct framing. The COA structure matters as much as the number.

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u/ismael_eriksen-3 points·1 year ago

What were the related substances listed individually?

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u/anecdata_annieOP718 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/amylin_amyamylin844 points·1 year ago
well that is my evening gone, thanks for the paper
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u/coa_collectorMOD569 points·1 year ago

Retitled to remove editorialising. Put the evidence in the body.

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u/zeynep_zielinski154 points·1 year ago

Mechanistically the bit that matters is purity. It explains most of the early profile and a decent chunk of the outcome.

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u/yusuf_nakamura195 points·1 year ago

Yeah, 96.8% area is not the problem, the missing impurity breakdown is the problem.

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u/sofia_danquah135 points·1 year ago

chromatogram or it did not happen

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u/low_appetite_lisa101 points·1 year ago

Yeah, 96.8% area is not the problem, the missing impurity breakdown is the problem.

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u/dario_boateng184 points·1 year ago

area% is not mass%, and here is exactly why it matters

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u/laila_wojcik360 points·1 year ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/low_appetite_lisa120 points·1 year ago

Not to be pedantic but COA and purity are being used interchangeably and they are not interchangeable in real life.

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u/reflux_report31 points·1 year ago

Slight fix: the number was 98.0, not 98.1. Decimal point, but a fairly consequential one.

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u/step_therapy_s13 points·1 year ago

Slight fix: the number was 98.0, not 98.1.

Yes, exactly this, and it is the bit that took me 84 weeks to accept.

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u/step_therapy_s216 points·1 year ago

Cosigning. The batch number is load-bearing information.

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u/clara_danquah66 points·1 year ago·edited

What were the related substances listed individually?

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u/yara_antonsen164 points·1 year ago

redact your own name, not the vendor's batch details

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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Independent HPLC and mass spec. The number you get is the number they found.

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