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c/cagrilintide·submitted 1 months ago by u/incretin_ivy

small win: satiety stopped being a problem at week 75

Cautionbranch of 9 comments

Something I noticed reading old threads that I have not seen said out loud. The advice on REDEFINE in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with…

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9 comments, started 1 months ago
u/signe_grimaldi-24 points·1 months ago

This is correct. The co-agonism is real.

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u/viktor_nkemelu1 point·1 months ago

Are we talking amylin or GLP-1 here?

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u/freya_baptista1 point·1 months ago

not approved anywhere, keep posts descriptive, not instructional

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u/incretin_ivyOPpharmacology1 point·1 months ago

Are we talking amylin or GLP-1 here?

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/incretin_ivyOPpharmacology1 point·1 months ago

The research community is small on cagrilintide. Forum lore changes faster than data.

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u/incretin_ivyMOD1 point·1 months ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/liv_dumitru1 point·1 months ago

Slight fix: the number was 99.1, not 99.2. Decimal point, but a fairly consequential one.

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u/teodor_lokken1 point·1 months ago

amylin is not a GLP-1, posts conflating them get corrected

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u/marta_ilunga1 point·1 months ago

Not convinced. The evidence does not support that reading.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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