small win: satiety stopped being a problem at week 75
Something I noticed reading old threads that I have not seen said out loud.
The advice on REDEFINE in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.
I have listed what I think the current consensus is below. Correct me — that is the point of posting it.
best — the order this archive was captured in
This is correct. The co-agonism is real.
Are we talking amylin or GLP-1 here?
not approved anywhere, keep posts descriptive, not instructional
Are we talking amylin or GLP-1 here?
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
The research community is small on cagrilintide. Forum lore changes faster than data.
Removed a chain here. The rule is one line long and it is not negotiable.
Slight fix: the number was 99.1, not 99.2. Decimal point, but a fairly consequential one.
amylin is not a GLP-1, posts conflating them get corrected
Not convinced. The evidence does not support that reading.
This is the "correlation is mechanism" thing again. You changed three variables at once.
REDEFINE phase 7 readouts are interesting but 7 person CagriSema is different from 7 trial CagriSema.
Yeah, amylin is doing different work than GLP-1.
The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does cagrilintide.
This is the "correlation is mechanism" thing again. You changed three variables at once.
Strongly agree. REDEFINE is phase 9, not final.
- 1This is correct. The co-agonism is real.9 comments in this branch · started by u/signe_grimaldi