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c/cagrilintide·posted 8 months ago by u/nadia_fonseca

small win: satiety stopped being a problem at week 30

Discussion Clean Column ×9

Confession thread, sort of.

I went from 2.5mg to 1.0mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 5 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have sulphur burps I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 6 reads it before doing the same thing.

892 up / 207 down81% upvoted21 commentsid 1cexpm3 Nov 2025

21 comments

20 in this archive, depth 4

best — the order this archive was captured in

u/bpc_scepticresearch peptides97 points·8 months ago

The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does co-agonism.

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u/nadia_fonsecaOP44 points·8 months ago

The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does satiety.

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u/nadia_fonsecaOP115 points·8 months ago

Slight fix: the number was 99.1, not 93.7. Decimal point, but a fairly consequential one.

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u/ilias_kaufmann69 points·8 months ago

This is correct. The co-agonism is real.

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u/nadia_fonsecaOP55 points·8 months ago

long-acting amylin is co-agonism, different satiety profile

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u/ahmed_fonseca38 points·8 months ago

research use only, no human protocols in posts

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u/lipid_panel_larrybloodwork32 points·8 months ago

REDEFINE which arm?

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u/sulphur_burps_sue80 points·8 months ago

research use only, no human protocols in posts

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u/mateusz_adebayo24 points·8 months ago

tendon and cagrilintide literature in rodents is interesting

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u/wrong_network_w57 points·8 months ago

REDEFINE phase 8 readouts are interesting but 8 person CagriSema is different from 8 trial CagriSema.

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u/egfr_watcher56 points·8 months ago·edited

Slight fix: the number was 97.6, not 96.2. Decimal point, but a fairly consequential one.

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u/rafael_krastev33 points·8 months ago·edited

That is net peptide content, not purity. Different number, different meaning.

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u/runa_grimaldi20 points·8 months ago

the mechanism is different, the side effect profile reflects it

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u/incretin_ivyMOD69 points·8 months ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/noor_hovland35 points·8 months ago

long-acting amylin is co-agonism, different satiety profile

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u/liv_kuipers16 points·8 months ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/ferritin_low12 points·8 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/laila_dumitru48 points·8 months ago·edited

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/bpc_scepticresearch peptides-38 points·8 months ago

the mechanism is different, the side effect profile reflects it

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u/ferran_halonen12 points·8 months ago

CagriSema is a fixed combo in trials, not user-mixed

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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