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c/cagrilintide·posted 1 year ago by u/noor_hovland

switched from 1.7mg to 5mg and the muscle cramps got better, not worse

Discussion Long Haul ×8 Slow Clap ×3

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking cagrilintide against triglycerides for 23 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

1,446 up / 154 down90% upvoted13 commentsid 1a6clz27 Mar 2025

13 comments

8 in this archive, depth 3

best — the order this archive was captured in

u/erez_perrin314 points·1 year ago

not approved anywhere, keep posts descriptive, not instructional

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u/niels_norgaard82 points·1 year ago

REDEFINE which arm?

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u/yannick_salinas241 points·1 year ago

REDEFINE readouts are phase 20 data

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u/ms_fragmenter188 points·1 year ago

This is correct. The co-agonism is real.

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u/ledger_modMOD104 points·1 year ago

Retitled to remove editorialising. Put the evidence in the body.

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u/blunt_coldbox149 points·1 year ago·edited

the co-agonism question is real and interesting

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u/georgi_chowdhury52 points·1 year ago

Rodent or human data?

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u/titration_marshalmod · c/semaglutide149 points·1 year ago

Yeah, amylin is doing different work than GLP-1.

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About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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