u/sena_teixeira

the dosing is steep, the the food-noise thing reports are real, and nobody knows the human safety yet

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

constipation is real, boring, and fixable

hair loss is real and usually reversible when you stabilize

the reship offer that never sends anything is worth noting

glucagon co-agonism has a different safety story

Disagree but this is the good kind of wrong — it is specific enough to be checked.

Maintenance for 17 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

Not to be pedantic but biopsy and survodutide are being used interchangeably and they are not interchangeable in real life.

Stalled for 12 weeks, changed nothing, and it started moving again on week 84.

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

heart rate and dose escalation need actual measurements, not impressions

Yes, exactly this, and it is the bit that took me 82 weeks to accept.

EMA notices are different from national ones

Disagree on that part. 99.2% and 98.1% on the same vial is normal.

phase 2 numbers are not maintenance numbers, cite the trial

Sceptical. If this were true we would see it reflected in the data and we do not.

Strongly agree. Describe your dose, your week number, and your titration speed or nobody can help.

pricing posts need date and currency

Strongly agree. The dispute resolved and the record stayed updated.

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.