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crossposted from c/glp1muscle by u/joaquin_trevino — [Results] 16 weeks on 1.7mg, full numbers, ask me anything boring
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c/survodutide·posted 1 year ago by u/trialwatch_theo

[Meta] proposal — a flair for dual agonist posts

Caution Receipts ×4 Cold Box ×2

Confession thread, sort of.

I went from 12.5mg to 5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 2 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have reflux I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 69 reads it before doing the same thing.

1,927 up / 169 down92% upvoted53 commentsid 1uz9k910 Sep 2024

53 comments

23 in this archive, depth 5

best — the order this archive was captured in

u/nadia_kjaer174 points·1 year ago

This is correct. Do not generalise from tirzepatide.

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u/santiago_villalobos102 points·1 year ago
genuine question, not being difficult: how do you know
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u/vitamin_d_void58 points·1 year ago

Crossposting this to c/bloodwork because the people who need it are not reading this community.

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u/trialwatch_theoOPtrial nerd42 points·1 year ago

Crossposting this to c/bloodwork because the people who need it are not reading this community.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/trialwatch_theoOPtrial nerd21 points·1 year ago

the heart rate signal is real in the data

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u/nora_oyelaran7 points·1 year ago

rodent survodutide is investigation only

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[removed]28 points·1 year ago

[removed by moderator]

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u/jarno_adeyemi50 points·1 year ago

hepatic fat and MASH are the story

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u/trialwatch_theoOPtrial nerd30 points·1 year ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/rafael_sjoberg42 points·1 year ago

the safety profile is not just tirzepatide amplified

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u/injection_site_iris23 points·1 year ago

the heart rate signal is real in the data

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u/endotoxin_elliemicro-7 points·1 year ago

glucagon co-agonism has a different safety story

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u/refund_ledger1 point·1 year ago

Not convinced. The evidence does not support that reading.

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u/refund_ledger26 points·1 year ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/yannick_petrov11 points·1 year ago

the heart rate signal is real in the data

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u/ismael_nwosu14 points·1 year ago

the heart rate signal is real in the data

Yes, exactly this, and it is the bit that took me 75 weeks to accept.

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u/meera_sandvik10 points·1 year ago

do not generalise from tirzepatide

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u/rania_marchand23 points·1 year ago

This is correct. Do not generalise from tirzepatide.

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u/tired_ledger_ftw5 points·1 year ago

Hepatic fat or MASH or what?

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u/elin_ferrari8 points·1 year ago

rodent dual agonist is investigation only

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u/sena_teixeira7 points·1 year ago

glucagon co-agonism has a different safety story

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u/teodor_szabo4 points·1 year ago

glucagon co-agonism has a different safety story

Adding to this: survodutide is doing more work than the comment implies.

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u/marisol_frisk5 points·1 year ago

Strongly agree. The safety story is separate.

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About c/survodutide

Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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