u/sena_teixeira

This is correct. Triple agonism is genuinely different.

resting heart rate moved up 21 bpm and settled back down when I stopped escalating

Every time this gets posted it hits the front page and every time someone has to re-explain it.

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

constipation is real, boring, and fixable

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

Respectfully this is a sample of one presented as a finding.

Yes, exactly this, and it is the bit that took me 73 weeks to accept.

constipation is real, boring, and fixable

Small correction: the trial was 5 weeks, not 18. Does not change your point but people will quote it.

cycle changes are real and under-researched

contraception interaction claims need citation

Strongly agree. The dispute resolved and the record stayed updated.

Crossposting this to c/t2dglp1 because the people who need it are not reading this community.

Disagree on that part. 95.1% and 99.3% on the same vial is normal.

constipation is real, boring, and fixable

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

Titration speed is a side-effect dial far more than an efficacy dial.

Genuine question — what concentration were you at?

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

Yeah, glucagon co-agonism is genuinely different.

TRIUMPH data is phase 2, not phase 3, smaller n and shorter