u/plain_titration

the amylin agonist pool is small, community is satiety

This is correct.

Adding to this: half-life is doing more work than the comment implies.

no commenting on anybody's body, comment on the process

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

I love that this community will spend 40 comments on a detail.

Disagree on that part. 93.7% and 99.3% on the same vial is normal.

REDEFINE phase 12 readouts are interesting but 12 person REDEFINE is different from 12 trial REDEFINE.

Did you time the injection consistently each week or was it more ad hoc?

Is that mechanism or speculation?

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

Did you get step therapy or outright denial?

Yeah, the incretin mechanism is doing the work here.

Disagree. What you are describing is consistent with non-scale victory, not with what you concluded.

Disagree but this is the good kind of wrong — it is specific enough to be checked.

This is a good question, genuinely.

text removes the comparison trap

Slight fix: the number was 97.6, not 99.2. Decimal point, but a fairly consequential one.

The thing nobody prepared me for was that the appetite does not come back for a long time after you stop.

the amylin agonist pool is small, community is amylin

amylin receptor distribution is different from GLP-1

Small correction: the trial was 17 weeks, not 32. Does not change your point but people will quote it.

REDEFINE phase 5 readouts are interesting but 5 person satiety is different from 5 trial satiety.