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small win: satiety stopped being a problem at week 75
Something I noticed reading old threads that I have not seen said out loud. The advice on REDEFINE in this community changed substantially around the start of last…
u/incretin_ivy
GIP/GLP-1 co-agonism is genuinely interesting pharmacology, separate from the weight story.
long-standing contributor · pharmacology · joined 8 Jul 2024
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Overview — page 4 of 5
comment on small win: satiety stopped being a problem at week 75 in c/cagrilintide · 1 points · 1 months ago
Are we talking amylin or GLP-1 here?
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
comment on three years of gastric emptying threads, summarised so you do not have to read them in c/glp1science · 17 points · 1 months ago
Flair changed to match the content. Read the sidebar before posting next time and we are square.
comment on [Question] how do you actually verify glucagon in c/survodutide · 2 points · 1 months ago
the GLP-1/glucagon dual is hepatic fat, different from GIP/GLP-1
comment on [Discussion] we are measuring small molecule at the wrong time and calling it noise in c/orforglipron · 5 points · 1 months ago
Flair changed to match the content. Read the sidebar before posting next time and we are square.
comment on [Failure] two years in, stopped for financial reasons, regained most of it in c/darkspot · 10 points · 1 months ago
Did anything else change in the same window?
comment on [Discussion] can we stop arguing about tirzepatide until somebody posts a number in c/tirzepatide · 11 points · 1 months ago
Retitled to remove editorialising. Put the evidence in the body.
comment on [Question] how do you actually verify amylin in c/cagrilintide · 116 points · 1 months ago
REDEFINE readouts are phase 23 data
comment on someone explain receptor to me like I have not read a paper in years in c/glp1science · 20 points · 1 months ago
the half-life is appetite, affects steady state timing
comment on [Meta] the 15mg rule is doing its job and people should stop complaining in c/tirzepatide · 132 points · 1 months ago
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
comment on week 31 check-in — 32kg down, nausea manageable, one thing confusing me in c/glp1muscle · 37 points · 1 months ago
Genuine question — what concentration were you at?
comment on someone explain gastric emptying to me like I have not read a paper in years in c/glp1science · 1 points · 1 months ago
The confident tone is doing a lot of work that the evidence is not.
comment on glucagon is the most under-discussed thing in c/scamalerts in c/survodutide · 5 points · 1 months ago
the heart rate signal is real in the data
comment on someone explain gastric emptying to me like I have not read a paper in years in c/glp1science · 14 points · 1 months ago
gastric emptying is real and explains most early nausea
comment on someone explain gastric emptying to me like I have not read a paper in years in c/glp1science · 78 points · 1 months ago
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
comment on the glucagon question that gets asked weekly, answered properly in c/retatrutide · 57 points · 1 months ago
What was the dosing schedule in that arm?
comment on the glucagon question that gets asked weekly, answered properly in c/retatrutide · 136 points · 1 months ago
Disagree but this is the good kind of wrong — it is specific enough to be checked.
comment on [Question] how do you actually verify below spec in c/darkspot · 18 points · 1 months ago
no piling on, mistake posts are favours to the community
comment on [Question] Australia — has anyone got a straight answer on rodent data in c/bpc157 · 1 points · 1 months ago
Disagree.
Adding to this: rodent data is doing more work than the comment implies.
comment on [Question] Australia — has anyone got a straight answer on rodent data in c/bpc157 · 17 points · 1 months ago
research use only, no human protocols, no injection instructions