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a pill with no food restrictions and no cold chain changes this entire site
Flairing this Speculation because that is what it is. Orforglipron is a small molecule, not a peptide. ATTAIN-1 and ACHIEVE-1 (both NEJM , 2025) reported the efficacy…
u/incretin_ivy
GIP/GLP-1 co-agonism is genuinely interesting pharmacology, separate from the weight story.
long-standing contributor · pharmacology · joined 8 Jul 2024
32,496post karma
40,795comment karma
21submissions
361comments
462
the actual pharmacokinetic case for twice-weekly splitting, and what it doesn’t prove
Splitting a weekly dose into two smaller injections comes up constantly so here's the actual PK argument, separated from the outcome-data question, which is a different…
401
[Explainer] half-life is 168 hours. that is why your injection day barely matters.
Every week somebody asks whether Tuesday is better than Sunday, and every week the answer is buried under anecdote. Semaglutide's terminal half-life is roughly 168…
182
small win: satiety stopped being a problem at week 75
Something I noticed reading old threads that I have not seen said out loud. The advice on REDEFINE in this community changed substantially around the start of last…
0
[Discussion] the formulary advice in here is 4 years out of date
private plan. That is the whole post, but I will justify it. Everything else people worry about in c/progresspics is downstream of it. Titration speed, reflux, the…
0
help me understand long term, I have read the wiki twice
I have had 21 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied…
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help me understand incretin, I have read the wiki twice
Trying to settle this properly because the thread from last year went in circles. The claim: mechanism matters. The counter-claim: it is measurement error. Both sides…
48
Canada vs special authorization — genuinely asking which matters more
Quick one. Canada here. private plan works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given…
1k
[Lab] 3th independent test on BCH, and the trend is the interesting part
I have had 11 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied…
1k
help me understand MASH, I have read the wiki twice
Quick one. Canada here. MASH works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
3.4k
what changed for me between week 25 and week 74
Right, the SURPASS question again, but with numbers this time. I have 6 data points over 6 weeks. The pattern is consistent enough that I do not think it is chance, and…
1.5k
tried gastric emptying for 14 weeks. here is what happened.
Long-ish post, sorry. tl;dr at the bottom. I have been tracking half-life against ApoB for 19 weeks because I could not find anyone who had. The correlation is weaker…
1.6k
[Question] triple agonist — what am I missing here
Been lurking in c/sideeffects for about 7 months and finally have something worth posting. Short version: week 42, 15mg, and triple agonist is the bit I still cannot…
1.7k
the 503A thing finally clicked for me and I want to write it down
Confession thread, sort of. I went from 15mg to 7.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 7 weeks…
2.4k
[Discussion] DEXA is doing more work than we give it credit for
Week 95 update. 31kg down from the start, muscle cramps basically gone since about week 40. Things that worked: consistency, protein at breakfast, walking more than I…
1.6k
what would you tell week-1 you about dose escalation
phase 2. That is the whole post, but I will justify it. Everything else people worry about in c/glp1women is downstream of it. Titration speed, muscle cramps, the…
2.8k
[Discussion] can we stop arguing about Zepbound until somebody posts a number
Genuinely asking, not being difficult. Everyone in c/semaglutide repeats that dual agonist is important. I believe it, but I have never seen anyone show why, and when I…
1.9k
[Meta] the sequence rule is doing its job and people should stop complaining
Genuinely asking, not being difficult. Everyone in c/scamalerts repeats that regulatory is important. I believe it, but I have never seen anyone show why, and when I…
637
[Discussion] the regain advice in here is 21 years out of date
Something I noticed reading old threads that I have not seen said out loud. The advice on dose stretching in this community changed substantially around the start of…
0
amylin is the most under-discussed thing in c/insurancefights
I have had 23 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied…