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c/glp1science·posted 1 months ago by u/milos_vanhecke

three years of gastric emptying threads, summarised so you do not have to read them

Explainer

Been lurking in c/researchpeptides for about 24 months and finally have something worth posting.

Short version: week 4, 0.5mg, and half-life is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 7 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 93.

160 up / 5 down97% upvoted20 commentsid 1sqhev26 Jun 2026

20 comments

14 in this archive, depth 5

best — the order this archive was captured in

u/incretin_ivyMOD17 points·1 months ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/gustav_vermeulen8 points·1 months ago·edited

amylin is not GLP-1, posts conflating them get corrected

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u/milos_vanheckeOP4 points·1 months ago

Receptor distribution explains why constipation hits gastric emptying but not incretin.

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u/noor_hovland6 points·1 months ago

Rodent, human, or in vitro?

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u/osman_eriksen4 points·1 months ago

central appetite signalling is real but people overweight it

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u/nadia_bakker3 points·1 months ago·edited

gastric emptying is real and explains most early nausea

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u/mod_ambulatoryadmin4 points·1 months ago

Respectfully this is a sample of one presented as a finding.

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u/aa_analysis_andy11 points·1 months ago
tl;dr for anyone scrolling: gastric emptying
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u/bastian_eriksen8 points·1 months ago

Respectfully this is a sample of one presented as a finding.

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u/camila_kowalski4 points·1 months ago

cite the paper: journal, year, first author, links optional

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u/milan_mensah6 points·1 months ago

Rodent, human, or in vitro?

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u/milos_vanheckeOP0 points·1 months ago

Receptor distribution explains why reflux hits gastric emptying but not incretin.

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u/maintenance_mode_maxmaintenance1 point·1 months ago·edited

cite the paper: journal, year, first author, links optional

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u/elin_lundgren1 point·1 months ago

Is that mechanism or speculation?

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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