[Meta] the 15mg rule is doing its job and people should stop complaining
Posting this because I searched for it and got nothing useful.
Setup: 12.5mg, week 16, constipation present but not ruining anything. I changed exactly one variable — SURPASS — and tracked it for 11 weeks.
Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.
Not medical advice, obviously. This is one person with a spreadsheet.
best — the order this archive was captured in
Flair changed to match the content. Read the sidebar before posting next time and we are square.
You have restated the marketing copy. What is the actual substance here.
You have restated the marketing copy.
Yes, exactly this, and it is the bit that took me 23 weeks to accept.
Not convinced. The evidence does not support that reading.
the 15mg is the top of the pen, not the required dose
Disagree but this is the good kind of wrong — it is specific enough to be checked.
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
The dual agonism story is real. The appetite is physically different from semaglutide alone.
SURMOUNT data is messier than STEP data but the weight loss is there
Did you stay on semaglutide or switch? The outcome is different if you are comparing.
the dual agonism hits different and that is why people describe it differently
the appetite change on tirz is more than just reduced hunger, it is different machinery
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SURMOUNT data is messier than STEP data but the weight loss is there
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.
Did you stay on semaglutide or switch? The outcome is different if you are comparing.
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
dual agonism is Mounjaro, do not generalise from semaglutide
the appetite change on tirz is more than just reduced hunger, it is different machinery
Strongly agree.
Disagree on that part. 99.0% and 98.9% on the same vial is normal.
do not crack the pen, we have been over this
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
Small correction: the trial was 5 weeks, not 35. Does not change your point but people will quote it.
the 15mg is the top of the pen, not the required dose
SURMOUNT data is messier than STEP data but the weight loss is there
Hard agree. The food noise disappears differently on the two compounds.
- 1Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.8 comments in this branch · started by u/incretin_ivy
- 2Strongly agree. Tirz is better than sema is not a claim without a comparator…6 comments in this branch · started by u/endpoint_creep