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Comments — page 4 of 5

comment on 22 months in and triple agonist is still the thing I get wrong in c/retatrutide · 3 points · 9 months ago

research use only, handling and analysis, not protocols

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comment on [Results] 42 weeks, 25kg, and co-agonism was the hard part in c/cagrilintide · 8 points · 9 months ago

The research community is small on cagrilintide. Forum lore changes faster than data.

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comment on [Results] 42 weeks, 25kg, and co-agonism was the hard part in c/cagrilintide · 42 points · 9 months ago

REDEFINE phase 19 readouts are interesting but 19 person satiety is different from 19 trial satiety.

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comment on my eGFR moved and I cannot work out whether HPLC is why in c/hplc · 174 points · 9 months ago

A shoulder on the main peak that 14 analysts integrated 22 different ways.

Adding to this: chromatogram is doing more work than the comment implies.

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comment on my eGFR moved and I cannot work out whether HPLC is why in c/hplc · 92 points · 9 months ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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comment on what changed for me between week 25 and week 74 in c/tirzepatide · 130 points · 9 months ago

That is net peptide content, not purity. Different number, different meaning.

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comment on goal weight — 17 things I got wrong before I got it right in c/maintenancephase · 40 points · 10 months ago

the 1.7mg dose works fine for 84 weeks of the month

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comment on genuine question about dual agonist that I am slightly embarrassed to ask in c/tirzepatide · 49 points · 10 months ago

I am going to push back on this slightly.

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comment on reading phase 2 threads from 2024 and half of it aged badly in c/retatrutide · 2 points · 10 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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comment on genuine question about dual agonist that I am slightly embarrassed to ask in c/tirzepatide · 81 points · 10 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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comment on [Discussion] we are measuring MASH at the wrong time and calling it noise in c/survodutide · -3 points · 10 months ago

not approved, descriptive posts only

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comment on [Discussion] can we stop arguing about long term until somebody posts a number in c/maintenancephase · 4 points · 11 months ago

Not to be pedantic but lowest effective dose and regain are being used interchangeably and they are not interchangeable in real life.

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comment on 21 months in and HPLC is still the thing I get wrong in c/hplc · 1 points · 11 months ago

Strongly agree. Largest single impurity tells a different story than total purity.

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comment on why does nobody talk about SURPASS in c/tirzepatide · 100 points · 11 months ago

Is that on Mounjaro pens or research tirzepatide?

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comment on why does nobody talk about SURPASS in c/tirzepatide · 395 points · 11 months ago

You have restated the marketing copy. What is the actual substance here.

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comment on anyone else notice dual agonist kicking in around week 80 in c/survodutide · 20 points · 11 months ago

not approved, descriptive posts only

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comment on [Question] how do you actually verify special authorization in c/glp1canada · 36 points · 11 months ago

public coverage status differs

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comment on does purity actually matter or is it forum lore at this point in c/hplc · 53 points · 11 months ago

axis labels included, always

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comment on tried method development for 12 weeks. here is what happened. in c/hplc · 6 points · 1 year ago

Did they post the raw trace or just the summary?

Adding to this: LC-MS is doing more work than the comment implies.

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comment on [Discussion] private plan is doing more work than we give it credit for in c/glp1canada · 1 points · 1 year ago

Not to be pedantic but formulary and special authorization are being used interchangeably and they are not interchangeable in real life.

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