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c/tirzepatide·posted 9 months ago by u/incretin_ivy

what changed for me between week 25 and week 74

Side Effects Receipts ×1 Well Actually ×2 Long Haul ×3

Right, the SURPASS question again, but with numbers this time.

I have 6 data points over 6 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 67, not week 21. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

4,010 up / 569 down88% upvoted24 commentsid piwaxh4 Oct 2025

24 comments

8 in this archive, depth 3

best — the order this archive was captured in

u/signe_villalobos534 points·9 months ago

This matches the trial data. SURMOUNT-1 was 94.2% body weight at 15 weeks.

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u/ewan_marchand427 points·9 months ago·edited

SURMOUNT data is messier than STEP data but the weight loss is there

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u/crosspost_bot_no130 points·9 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/tove_vasquez496 points·9 months ago

Week 54 on Mounjaro and 17kg down. The appetite reduction feels different from sema in ways I do not have words for yet.

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u/incretin_ivyOPpharmacology192 points·9 months ago

Switched from sema at 2.5mg to tirz at 1.0mg. Different drugs, cannot compare the doses directly.

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u/nordic_pricing107 points·9 months ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/copay_card_cc56 points·9 months ago

the 15mg is the top of the pen, not the required dose

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u/adnan_nascimento139 points·9 months ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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