why does nobody talk about SURPASS
Week 81 update. 37kg down from the start, early fullness basically gone since about week 38.
Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness.
The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.
Happy to answer anything. Please do not ask me what dose you should be on.
best — the order this archive was captured in
You have restated the marketing copy. What is the actual substance here.
the 15mg is the top of the pen, not the required dose
Is that on Mounjaro pens or research tirzepatide?
the 15mg is the top of the pen, not the required dose
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
SURMOUNT data is messier than STEP data but the weight loss is there
stalled on sema, tried tirz, and the curves were actually different shapes
Not to be pedantic but tirzepatide and GIP are being used interchangeably and they are not interchangeable in real life.
What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.
the appetite change on tirz is more than just reduced hunger, it is different machinery
SURMOUNT data is messier than STEP data but the weight loss is there
You have restated the marketing copy. What is the actual substance here.
the GIP side does different things than the GLP-1 side, that is the point
Not to be pedantic but Mounjaro and 15mg are being used interchangeably and they are not interchangeable in real life.
the early fullness from tirz is different, not necessarily worse
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
week 83 on Mounjaro and the appetite profile is genuinely different from sema
Switched from sema at 0.25mg to tirz at 15mg. Different drugs, cannot compare the doses directly.
the dual agonism hits different and that is why people describe it differently
the reflux from tirz is different, not necessarily worse
Is that on Mounjaro pens or research tirzepatide?
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nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
Disagree on that part. 96.8% and 96.2% on the same vial is normal.
Disagree but this is the good kind of wrong — it is specific enough to be checked.
Titration speed is a side-effect dial far more than an efficacy dial.
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
SURMOUNT data is messier than STEP data but the weight loss is there
How long at each step before you escalated?
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