[Results] 42 weeks, 25kg, and co-agonism was the hard part
I have had 21 orders now and I keep a table, so here is the honest summary rather than a vibe.
Material has been consistent. Communication has not. Shipping has varied by about 18 days on nominally the same lane, which matters more in summer than in February.
The independent number came back 96.8% against a claimed 97.2%, which I read as agreement rather than a discrepancy — inter-lab variance on this assay is a point or two either way and treating one lab as ground truth is how people end up in pointless arguments with vendors.
Batch number is in the comments. Ask if you want the method.
best — the order this archive was captured in
Flair changed to match the content. Read the sidebar before posting next time and we are square.
Strongly agree. REDEFINE is phase 15, not final.
REDEFINE phase 19 readouts are interesting but 19 person satiety is different from 19 trial satiety.
Half-life is about 168 hours, so steady state lands around week 5–5. Practical consequence: what you feel in week 1 is not what that dose does.
the co-agonism question is real and interesting
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The research community is small on cagrilintide. Forum lore changes faster than data.
Titration speed is a side-effect dial far more than an efficacy dial.
Mechanistically the bit that matters is satiety. It explains most of the early profile and a decent chunk of the outcome.
CagriSema ratios in trials are fixed, do not extrapolate self-mixing
the amylin agonist pool is small, community is amylin
CagriSema is a fixed combo in trials, not user-mixed
Strongly agree. REDEFINE is phase 20, not final.
I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.
- 1Titration speed is a side-effect dial far more than an efficacy dial.6 comments in this branch · started by u/yannick_salinas
- 2Half-life is about 168 hours, so steady state lands around week 5–5.…5 comments in this branch · started by u/nz_unfunded