GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Single comment threadYou are looking at one branch of anyone else notice endpoint kicking in around week 19 — 45 comments in the full submission. View in context.
2.2k
c/trialwatch·submitted 4 months ago by u/rt_shift_reggie

anyone else notice endpoint kicking in around week 19

Readoutbranch of 6 comments

Genuinely asking, not being difficult. Everyone in c/compounding repeats that hazard ratio is important. I believe it, but I have never seen anyone show why, and when I search I get 2 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

Read the full submission and all 45 comments →

This branch

6 comments, started 4 months ago
u/trialwatch_theotrial nerd247 points·4 months ago

Titration speed is a side-effect dial far more than an efficacy dial.

replysharereportpermalink
u/bastian_ekstrom-3 points·4 months ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

replysharereportpermalink
u/yusuf_achebe-5 points·4 months ago

off-label use data is different from approved-indication data

replysharereportpermalink
u/iman_castellanos198 points·4 months ago·edited

Titration speed is a side-effect dial far more than an efficacy dial.

Yes, exactly this, and it is the bit that took me 91 weeks to accept.

replysharereportpermalink
u/joaquin_stanescu58 points·4 months ago·edited

Is that absolute or relative risk reduction?

replysharereportpermalink
[deleted]26 points·4 months ago

[deleted]

replysharereportpermalink

← back to the whole thread

About c/trialwatch

Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

34kmembers
95submissions
Nov 2023created
submissions / month, last year
Sponsored

Janoshik Analytical

Independent HPLC and mass spec. The number you get is the number they found.

janoshik.comSponsored

GL Biochem (Shanghai)

Custom peptides and amino acids direct from the manufacturer since 1998. ISO 9001 / cGMP. Batch COA every order.

glbiochem.net
More in c/trialwatch
c/trialwatch rules
  1. Press-release-only posts must be flaired Press Release until a publication exists.
  2. Give the trial name, phase, n, and primary endpoint in the body.
  3. Relative risk reduction alone is not a result. Show the absolute numbers.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Full rules and how they are enforced →
Moderators
u/trialwatch_theou/forest_plot_fionau/hazard_ratio_halu/renal_outcomes_r
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.

Full disclaimer →