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c/trialwatch·submitted 4 months ago by u/rt_shift_reggie

anyone else notice endpoint kicking in around week 19

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Genuinely asking, not being difficult. Everyone in c/compounding repeats that hazard ratio is important. I believe it, but I have never seen anyone show why, and when I search I get 2 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

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8 comments, started 4 months ago
u/ferran_dahlberg196 points·4 months ago

Yeah, absolute numbers matter more than the press release.

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u/nhs_waitlist_nUK147 points·4 months ago

Phase 2 or phase 3?

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u/camila_vasquez77 points·4 months ago

the 7 week readout is different from the 13 week readout

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u/naomi_ekstrom0 points·4 months ago

the relative risk reduction in headlines is not the whole story

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u/first_hundred1 point·4 months ago

the relative risk reduction in headlines is not the whole story

Adding to this: hazard ratio is doing more work than the comment implies.

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u/karl_fischer_kev1 point·4 months ago

event rates are more informative than hazard ratios alone

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u/yusuf_achebe1 point·4 months ago

give the trial name, phase, n, and primary endpoint in the body

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u/trialwatch_theotrial nerd57 points·4 months ago

STEP 1 readout: 99.3% mean weight loss, absolute numbers matter. Spread around that mean is enormous.

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