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c/trialwatch·posted 1 year ago by u/yannick_salinas

the SELECT thing finally clicked for me and I want to write it down

Paper Clean Column ×1 Cold Box ×3 Well Actually ×3

Week 66 update. 22kg down from the start, muscle cramps basically gone since about week 11.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with muscle cramps.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

3,862 up / 369 down91% upvoted39 commentsid 4yxxwb18 Feb 2025

39 comments

9 in this archive, depth 4

best — the order this archive was captured in

u/tove_ogunleye578 points·1 year ago

Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.

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u/oskar_ibarra167 points·1 year ago

event rates are more informative than hazard ratios alone

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u/kaia_cabrera529 points·1 year ago·edited

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/yannick_salinasOP394 points·1 year ago

Not to be pedantic but SURMOUNT and STEP are being used interchangeably and they are not interchangeable in real life.

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u/yannick_salinasOP212 points·1 year ago

SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.

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u/rohan_cardoso146 points·1 year ago

dropout handling matters, especially on GI-heavy populations

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u/milos_vanhecke277 points·1 year ago

Not to be pedantic but TRIUMPH and SURPASS are being used interchangeably and they are not interchangeable in real life.

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u/naomi_ekstrom252 points·1 year ago

off-label use data is different from approved-indication data

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Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

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