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c/trialwatch·posted 1 year ago by u/piotr_bruun

three years of hazard ratio threads, summarised so you do not have to read them

Discussion Cold Box ×2 Well Actually ×3 Receipts ×1

STEP. That is the whole post, but I will justify it.

Everything else people worry about in c/orforglipron is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort STEP out first, and almost nobody does.

I say this having got it wrong for 18 months. My eGFR was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.

3,065 up / 110 down97% upvoted42 commentsid 4yusec6 Jul 2025

42 comments

3 in this archive, depth 2

best — the order this archive was captured in

u/ferran_dahlberg193 points·1 year ago

This is correct. Discontinuation arms show the regain reality.

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u/cold_chromatogram31114 points·1 year ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/trialwatch_theoMOD60 points·1 year ago·edited

Tracking number removed. It identifies both ends of a shipment.

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Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

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