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c/trialwatch·submitted 5 months ago by u/anders_karlsen

[Meta] the STEP rule is doing its job and people should stop complaining

Readoutbranch of 9 comments

FLOW. That is the whole post, but I will justify it. Everything else people worry about in c/coa is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort FLOW out first, and almost nobody does. I say this having got it wrong for 14 months. My hs-CRP was the…

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9 comments, started 5 months ago
u/nordic_pricing157 points·5 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/hugo_bergstrom73 points·5 months ago

off-label use data is different from approved-indication data

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u/yusuf_ramos43 points·5 months ago

off-label use data is different from approved-indication data

Yes, exactly this, and it is the bit that took me 20 weeks to accept.

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u/hedda_adeyemi0 points·5 months ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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u/prior_auth_painappeals0 points·5 months ago

dropout handling matters, especially on GI-heavy populations

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