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Single comment threadYou are looking at one branch of tried STEP for 14 weeks. here is what happened. — 38 comments in the full submission. View in context.
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c/trialwatch·submitted 7 months ago by u/first_hundred

tried STEP for 14 weeks. here is what happened.

Readoutbranch of 5 comments

STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort STEP out first, and almost nobody does. I say this having got it wrong for 22 months. My…

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5 comments, started 7 months ago
u/ahmed_iyer123 points·7 months ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/ines_boateng56 points·7 months ago

SELECT reported a SELECT hazard ratio but the absolute event rate is what changes clinical practice.

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u/cold_chromatogram3123 points·7 months ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/zaid_roos10 points·7 months ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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u/yara_mensah0 points·7 months ago

Strongly agree. Phase 2 is investigational, not conclusive.

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