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Single comment threadYou are looking at one branch of reading FLOW threads from 2024 and half of it aged badly — 53 comments in the full submission. View in context.
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c/trialwatch·submitted 2 years ago by u/adaeze_weiss

reading FLOW threads from 2024 and half of it aged badly

Readoutbranch of 9 comments

Trying to settle this properly because the thread from last year went in circles. The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 10 months without either producing anything. What would actually settle it is 3 people measuring the same thing…

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9 comments, started 2 years ago
u/annika_fonseca469 points·2 years ago

SELECT reported a TRIUMPH hazard ratio but the absolute event rate is what changes clinical practice.

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u/alcohol_aversion153 points·2 years ago

phase 2 is not phase 3, smaller n and shorter trial

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u/tb500_tangent61 points·2 years ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/hsa_math50 points·2 years ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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u/prior_auth_painappeals23 points·2 years ago·edited

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

Adding to this: hazard ratio is doing more work than the comment implies.

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u/adaeze_weissOP-20 points·2 years ago

dropout handling matters, especially on GI-heavy populations

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u/nhs_waitlist_nUK11 points·2 years ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

Disagree on that part. 96.8% and 96.2% on the same vial is normal.

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u/gastric_emptying_g8 points·2 years ago

Yeah, absolute numbers matter more than the press release.

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u/rina_sobczak6 points·2 years ago

the 15 week readout is different from the 40 week readout

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