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c/trialwatch·posted 11 months ago by u/tove_ogunleye

reading STEP threads from 2024 and half of it aged badly

Readout Receipts ×5

Trying to settle this properly because the thread from last year went in circles.

The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 23 months without either producing anything.

What would actually settle it is 19 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

488 up / 190 down72% upvoted16 commentsid 3uwdmg25 Aug 2025

16 comments

8 in this archive, depth 2

best — the order this archive was captured in

u/renal_outcomes_rMOD40 points·11 months ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/draw_up_dizzy9 points·11 months ago

This is correct. Discontinuation arms show the regain reality.

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u/ahmed_iyer25 points·11 months ago·edited

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/anders_kuusela21 points·11 months ago

Yeah, absolute numbers matter more than the press release.

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u/cesar_ivaturi10 points·11 months ago

number-needed-to-treat is the house dialect

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u/joaquin_trevino-2 points·11 months ago

give the trial name, phase, n, and primary endpoint in the body

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u/forest_plot_fionastats1 point·11 months ago

absolute risk reduction, not relative risk reduction, that is how you decide

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u/yara_mensah8 points·11 months ago

This is correct. Discontinuation arms show the regain reality.

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About c/trialwatch

Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

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