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c/trialwatch·submitted 2 years ago by u/hsa_math

someone explain endpoint to me like I have not read a paper in years

Readoutbranch of 4 comments

I have had 18 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied by about 38 days on nominally the same lane, which matters more in summer than in February. The independent number came back 98.4% against a claimed…

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4 comments, started 2 years ago
u/cloudy_vial_carol92 points·2 years ago

dropout handling matters, especially on GI-heavy populations

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u/hsa_mathOP65 points·2 years ago

dropout handling matters, especially on GI-heavy populations

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/hub_opssite staff16 points·2 years ago

dropout handling matters, especially on GI-heavy populations Counter-anecdote: opposite result, same dose.

Adding to this: hazard ratio is doing more work than the comment implies.

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u/sofia_ferreira5 points·2 years ago

absolute risk reduction, not relative risk reduction, that is how you decide

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Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

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