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c/trialwatch·submitted 1 year ago by u/marit_laurent

reading endpoint threads from 2024 and half of it aged badly

Discussionbranch of 6 comments

Genuinely asking, not being difficult. Everyone in c/compounding repeats that hazard ratio is important. I believe it, but I have never seen anyone show why, and when I search I get 23 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

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6 comments, started 1 year ago
u/sanne_laurent-4 points·1 year ago

Disagree. What you are describing is consistent with SURPASS, not with what you concluded.

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u/slow_logbook_notes301 point·1 year ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/marit_laurentOP-5 points·1 year ago

SELECT reported a SURMOUNT hazard ratio but the absolute event rate is what changes clinical practice.

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u/cold_chromatogram311 point·1 year ago

Disagree.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/ferran_dahlberg1 point·1 year ago

the discontinuation arms are the interesting part, not the STEP endpoints

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u/marit_laurentOP1 point·1 year ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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