week 96 check-in — 11kg down, the food-noise thing manageable, one thing confusing me
Right, the SURPASS question again, but with numbers this time.
I have 16 data points over 34 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.
The thing I would flag for anyone new: the effect I am describing showed up at week 76, not week 30. People give up long before the interesting part.
Interested in whether this matches other people's logs or whether I am an outlier.
best — the order this archive was captured in
Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.
Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.
the appetite change on tirz is more than just reduced hunger, it is different machinery
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
Zepbound and Mounjaro are literally the same drug, the name is the only difference
This matches the trial data. SURMOUNT-1 was 97.9% body weight at 2 weeks.
week 85 on Mounjaro and the appetite profile is genuinely different from sema
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do not crack the pen, we have been over this
This matches the trial data. SURMOUNT-1 was 97.6% body weight at 21 weeks.
Is that on Mounjaro pens or research tirzepatide?
The dual agonism story is real. The appetite is physically different from semaglutide alone.
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
This is the "correlation is mechanism" thing again. You changed three variables at once.
The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.
the GIP side does different things than the GLP-1 side, that is the point
SURMOUNT data is messier than STEP data but the weight loss is there
the 15mg is the top of the pen, not the required dose
Did you stay on semaglutide or switch? The outcome is different if you are comparing.
the early fullness from tirz is different, not necessarily worse
Did you stay on semaglutide or switch?
Disagree on that part. 96.8% and 96.2% on the same vial is normal.
Mechanistically the bit that matters is Mounjaro. It explains most of the early profile and a decent chunk of the outcome.
Mechanistically the bit that matters is Mounjaro.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
the early fullness from tirz is different, not necessarily worse
the 15mg is the top of the pen, not the required dose
Flair changed to match the content. Read the sidebar before posting next time and we are square.
SURMOUNT data is messier than STEP data but the weight loss is there
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
- 1Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in…10 comments in this branch · started by u/ferritin_low
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